Biostimulatory Fillers

Conveniently located to serve the areas of New York, NY

Biostimulatory fillers are a revolutionary approach to facial rejuvenation that not only add volume but also stimulate the body’s natural collagen production. This dual action results in a more youthful and revitalized appearance. Among the most popular biostimulatory fillers are Radiesse and Sculptra, both of which offer unique benefits for those looking to improve their skin’s texture and firmness.

Before and After Photos

What Are Biostimulatory Fillers?

Unlike dermal fillers that primarily add volume, biostimulatory fillers work by stimulating the body’s natural collagen production. Collagen is a vital protein that provides structure and elasticity to the skin. Collagen production can decrease by approximately 1% per year starting in our mid-20s, leading to wrinkles, sagging, and loss of firmness. Biostimulatory fillers address this issue by encouraging the skin to produce more collagen, thereby improving the skin’s overall quality and appearance over time.

Why Choose Dr. Jennifer Levine?

  • Top 1% injector in the U.S.
  • 25+ years in facial plastic surgery with expert knowledge in facial anatomy.
  • An expert in Facial Balancing.

Radiesse: Enhancing Structure and Volume

Radiesse is a biostimulatory filler composed of calcium hydroxylapatite (CaHA) microspheres suspended in a gel carrier. When injected, Radiesse provides immediate volume and lift to the treated areas. Over time, the CaHA microspheres stimulate the production of natural collagen, which helps maintain the results long after the initial effects have worn off. Radiesse is particularly effective for:

  • Smoothing moderate to severe facial wrinkles and folds
  • Restoring volume to the cheeks and jawline
  • Rejuvenating the hands

Sculptra: Gradual and Long-Lasting Rejuvenation

Sculptra is made from poly-L-lactic acid (PLLA), a biocompatible substance that has been used in medical treatments for decades. Unlike other fillers, Sculptra works gradually by stimulating collagen production deep within the skin. This process results in a natural-looking improvement in skin thickness and elasticity over several months. Sculptra is ideal for:

  • Treating deep lines, creases, and folds
  • Restoring facial volume lost due to aging or illness
  • Improving the overall texture and tone of the skin

How Biostimulatory Fillers Differ from Traditional Dermal Fillers

Traditional dermal fillers, such as hyaluronic acid fillers, deliver immediate results by adding volume directly to the treated areas. These fillers are effective for achieving instant improvements, smoothing wrinkles, and enhancing facial contours. However, their effects are temporary, typically lasting between 6 to 18 months, and they do not stimulate collagen production.

In contrast, biostimulatory fillers like Radiesse and Sculptra offer a dual benefit. Not only do they provide immediate volume and lift, but they also stimulate the skin’s natural collagen production. This process enhances the skin’s structural integrity and elasticity, resulting in longer-lasting and more natural-looking results. Over time, as collagen levels increase, the skin’s texture, firmness, and overall appearance continue to improve, extending the benefits well beyond the initial treatment period.

Key Differences:

  • Immediate vs. Long-Term Results: Traditional fillers provide immediate but temporary volume; biostimulatory fillers offer immediate volume with long-term collagen production.
  • Duration: Traditional fillers last 6 to 18 months; biostimulatory fillers have longer-lasting effects due to collagen stimulation.
  • Mechanism: Traditional fillers add volume directly; biostimulatory fillers add volume and stimulate collagen production.
  • Substance: Traditional fillers are usually hyaluronic acid; biostimulatory fillers include Radiesse (CaHA) and Sculptra (PLLA).

During your consultation, Dr. Jennifer Levine, a top facial plastic surgeon in NYC, will select the most appropriate filler to address your aesthetic concerns.

Complementary Treatments

To maximize the benefits of biostimulatory fillers, they can be combined with other rejuvenating treatments. Some complementary options include:

Laser Skin Resurfacing

Laser skin resurfacing treatments can improve the skin’s texture and tone by targeting the outer layers of the skin. This treatment is particularly effective for reducing fine lines, sun damage, and acne scars. Combining laser skin resurfacing with biostimulatory fillers can enhance overall skin rejuvenation, providing both surface and deep improvements.


Ultherapy uses focused ultrasound energy to stimulate collagen production deep within the skin. This non-invasive treatment can lift and tighten the skin on the face, neck, and décolletage. When used in conjunction with biostimulatory fillers, Ultherapy can enhance the lifting and tightening effects, resulting in a more youthful appearance.

Microneedling with PRP / PRFM

Microneedling with platelet-rich plasma (PRP) and PRFM (platelet-rich fibrin matrix) involves creating micro-injuries in the skin to stimulate collagen production, while PRP enhances healing and rejuvenation. This treatment can improve skin texture, tone, and overall quality. Combining microneedling with biostimulatory fillers can further boost collagen production and enhance overall results.


Exosome therapy is a cutting-edge treatment that uses exosomes, tiny vesicles derived from stem cells, to promote skin regeneration and healing. Exosomes contain growth factors and proteins that enhance the skin’s repair processes. When combined with biostimulatory fillers and microneedling, exosomes have shown to significantly improve skin quality, accelerate healing, and boost collagen production, leading to a more youthful and radiant complexion.

Benefits of Combining Treatments

Combining biostimulatory fillers with other anti-aging and rejuvenating treatments offers several benefits:

  • Comprehensive Rejuvenation: Address multiple skin concerns at different levels for a more complete transformation.
  • Enhanced Results: Synergistic effects from combined treatments can lead to better and longer-lasting results.
  • Customized Treatment Plans: Tailored approaches to meet individual needs and aesthetic goals.

Schedule a Consultation

If you are interested in enhancing your appearance with biostimulatory fillers and complementary treatments, schedule a consultation to discuss your goals and create a personalized treatment plan.

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